Predictive Value of Liver Biomarkers in Assessing Severity of RNA Virus-Related Chronic Liver Disease
DOI:
https://doi.org/10.66238/jaeee15Keywords:
Hepatitis C Virus (HCV), Hepatitis E Virus (HEV), Liver Function Biomarkers, Chronic Liver Disease (CLD), Prognostic IndicatorsAbstract
RNA-based viruses such as hepatitis C virus (HCV) and hepatitis E virus (HEV) are principal etiological agents of chronic liver disease (CLD) worldwide, particularly in low- and middle-income countries. Liver function biomarkers, especially enzymatic and synthetic indices, serve as accessible and cost-effective tools for assessing hepatic injury, disease progression, and treatment response. This article explores the predictive value of transaminases (ALT, AST), cholestatic markers (ALP, GGT, bilirubin), and synthetic markers (albumin, prothrombin time) in stratifying the severity of chronic liver dysfunction associated with HCV and HEV. Through molecular and clinical insights, the study highlights how biomarker patterns can serve as proxies for viral activity, fibrosis progression, and hepatic decompensation. An evidence-based framework is proposed for their interpretation in both diagnostic and prognostic contexts.
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Copyright (c) 2025 Elena R. Vasquez
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