Correlation between RNA virus Load and Liver Function Biomarkers in Chronic Hepatic Disorders

Authors

  • Julia Reinhardt Department of Gastroenterology, Heidelberg University Hospital, Germany

DOI:

https://doi.org/10.66238/jaeee13

Keywords:

Hepatitis C Virus, Hepatitis E Virus, RNA viral load, ALT, Liver biomarkers

Abstract

Chronic liver disease (CLD) caused by RNA-based viruses such as Hepatitis C Virus (HCV) and Hepatitis E Virus (HEV) poses a significant global health burden. The quantitative relationship between viral load and liver function biomarkers can provide critical insights into disease progression, severity, and therapeutic response. This study investigates the correlation between RNA virus load and key biochemical markers including ALT, AST, ALP, bilirubin, albumin, and INR in a cohort of patients with chronic HCV and HEV infections. Our findings reveal a moderate to strong positive correlation between viral load and transaminase levels, alongside a negative correlation with serum albumin and synthetic function markers. These results emphasize the utility of viral quantification in conjunction with liver panel assessments for comprehensive disease monitoring.

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Published

2025-12-31